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HUMAN IMMUNITY
Adaptive immune memory is an evolutionary feature of higher vertebrates that can provide protection against reinfection by the same pathogen. This protection is primarily mediated by T and B cells and the effector molecules they produce. We are interested in identifying the molecular targets of protective immune responses against arboviruses, and how these responses may be similar or different following vaccination compared to natural infection.
CURRENT PROJECTS
DOES CONGENITAL ZIKA INFECTION ELICIT DURABLE, ZIKA-SPECIFIC MEMORY T AND B CELLS?
DOES THE PREGNANT STATE ALTER THE PHENOTYPE AND FUNCTION OF FLAVIVIRUS-SPECIFIC T CELLS?
WANING AND DECAY: WHAT IS THE RELATIONSHIP BETWEEN SEROLOGICAL ACTIVITY TO ZIKA IN MOM AND BABY IN EARLY INFANCY?
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